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Main Scientific interests
– Physical and physiological basis of fMRI
– Multi-modal imaging (simultaneous PET-MRI, EEG-MRI)
– Measuring cerebral blood flow using arterial spin labeling MRI
in healthy subjects and stroke patients
Education & Professional Experience
- 2009 Organizer of the ‘fMRI course’ of the European Society
for Magnetic Resonance in Medicine and Biology (ESMRMB)'2008-present Editorial
Board of Frontiers of Neuroenergetics
- 2008-present Editorial Board of NeuroImage
- 2007-2009 Chair of the study group “Current Issues of Brain Function”
of the International Society for Magnetic Resonance in Medicine (ISMRM)
- 2004-present Head of human functional imaging
High Field MR Center
Max-Planck-Institute for Biological Cybernetics
- 2003-2004 Postdoctorate Researcher in functional MRI
(Supervisor: Prof. Dr. Richard B. Buxton)
Center for Functional Magnetic Resonance Imaging
University of California, San Diego
September 2003 Ph.D. Physics, Humboldt Universität, Berlin
- 1999-2003 Graduate Student in near-infrared spectroscopy and functional
MRI
(Supervisor: Prof. Dr. Arno Villringer)
Clinical Research Group
Humboldt Universitaet, Berlin
- September 1997 Diploma Physics Technische Universität, Berlin
(awarded with the 'Hereaus Price')
Book
- K. Ugurbil, K. Uludag, L. Berliner, “Functional MRI”, Springer
publisher (in preparation).
Book chapters
- K.Uludag, D.J. Dubowitz, R. B. Buxton, “Basic Principles of functional
MRI”, In R. Edelman, J. Hesselink, M. Zlatkin, editors, Clinical
MRI, pages 249-287. Elsevier, San Diego, 2005
- K. Ugurbil, W. Chen, N. Harel, P. van de Moortele, X. Hu, K. Uludag.
MRI of Brain Function. In Encyclopedia of Biomedical Engineering, pages
1-24. 2006
Peer-reviewed Publications:
30. K. Uludag, B. Müller-Bierl, K. Ugurbil, “An integrative
model for neuronal activity-induced signal changes for gradient and spin
echo functional imaging”, Neuroimage (in press).
29. A. Thielscher, A. Reichenbach, K. Ugurbil, K. Uludag, „The cortical
site of visual suppression by Transcranial Magnetic Stimulation”,
Cerebral Cortex (in press).
28. K.Uludag, A. Evans, V. Della-Maggiore, G. Murer, E. Amaro, O. Sierra,
P. Valdés-Hernandez, V. Medina, P. Valdés-Sosa, „Latin
American Brain Mapping Network“, NeuroImage (in press).
27. K.Uludag, A. Evans, V. Della-Maggiore, G. Murer, E. Amaro, O. Sierra,
P. Valdés-Hernandez, V. Medina, P. Valdés-Sosa, „Latin
American Brain Mapping Network“, International Journal for Bioelectromagnetism
10(4), 281-299 (2008).
26. S. Sadaghiani, K. Ugurbil, K. Uludag, “Neural activity-induced
modulation of BOLD post-stimulus undershoot independent of the positive
signal”, Magnetic Resonance Imaging (in press).
25. M. Cavusoglu, J. Pfeuffer, K. Ugurbil, K. Uludag, “Comparison
of Pulsed Arterial Spin Labeling Encoding and Absolute Perfusion Quantification
Schemes”, Magnetic Resonance Imaging (in press).
24. K. Uludag, “Transient and sustained BOLD responses to sustained
stimulation”, Magnetic Resonance Imaging, 26(7), 863-9 (2008).
23. A.C. Zappe, K. Uludag, N.K. Logothetis, “Direct measurement
of oxygen extraction with fMRI using 6% CO(2) inhalation.”, Magnetic
Resonance Imaging, 26(7), 961-7 (2008).
22. E. Yacoub, K. Uludag, K. Ugurbil, N. Harel, “Decreases in ADC
observed in tissue areas during activation in cat visual cortex at 9.4
T using high diffusion sensitization”, Magnetic Resonance Imaging,
26(7), 889-96 (2008).
21. B. Yesilyurt, K. Ugurbil, K. Uludag, “Dynamics and nonlinearities
of BOLD response at very short stimulus durations”, Magnetic Resonance
Imaging, 26(7), 853-62 (2008).
20. A.C. Zappe, K. Uludag, N.K. Logothetis, “The Influence of Moderate
Hypercapnia on Neural Activity in the Anesthetized Nonhuman Primate”,
Cerebral Cortex, 18(11), 2666-73 (2008).
19. M.S. Judenhofer, H.F. Wehrl, D.F. Newport, C. Catana, S.B. Siegel,
M. Becker, A. Thielscher, M. Kneilling, M. Lichy, M. Eichner, K. Klingel,
G. Reischl, S. Widmaier, M. Röcken, R.E. Nutt, H.-J. Machulla, K.
Uludag, S.R. Cherry, C.D. Claussen, B.J. Pichler, “Simultaneous
PET/MRI: A new Approach for Functional and Morphological Imaging”,
Nature Medicine 14(4), 459-65 (2008).
18. B. M. Mueller-Bierl, K. Uludag, P. L. Pereira, F. Schick, “Magnetic
field distribution and signal decay in functional MRI in very high fields
(up to 9.4 T) using Monte Carlo diffusion modeling”, International
Journal of Biomedical Imaging, Article ID 70309 (2007).
17. J. Steinbrink, T. Fischer, H. Kuppe, R. Hetzer, K. Uludag, H. Obrig,
W. M. Kuebler, "Relevance of depth resolution for cerebral blood
flow monitoring by near-infrared spectroscopic bolus tracking during cardiopulmonary
bypass", J Thorac Cardiovasc Surg., 132(5), 1172-8 (2006).
16. N. Harel, K. Ugurbil, K. Uludag, E. Yacoub, "Frontiers of Brain
Mapping using MRI", Journal of Magnetic Resonance in Medicine, 23(6),
945-957 (2006).
15. M. L. Schroeter, T. Kupka, T. Mildner, K. Uludag, Y. von Cramon, "Investigating
the post-stimulus undershoot of the BOLD signal - a simultaneous fMRI
and NIRS study", Neuroimage, 30(2), 349-58 (2005).
14. R. B. Buxton, K. Uludag, D. J. Dubowitz, T. T. Liu, "Modeling
the hemodynamic response to brain activation", Neuroimage 23(S1),
S220-S233 (2004).
13. T. T. Liu, Y. Behzadi, K. Restom, K. Uludag, K. Lu, G. T. Buracas,
D. J. Dubowitz, R. B. Buxton, "Caffeine alters the temporal dynamics
of the visual BOLD response", Neuroimage 23(4), 1402-13 (2004).
12. R. B. Buxton, K. Uludag, D. J. Dubowitz, “Investigating the
physiology of brain activation with fMRI”, Proceedings of SPIE 5369,
207-18 (2004).
11. K. Uludag, D. J. Dubowitz, E. J. Yoder, K. Restom, T. T. Liu, R. B.
Buxton, “Coupling of cerebral blood flow and oxygen metabolism during
physiological activation and deactivation measured with fMRI”, Neuroimage
23(1), 148-55 (2004).
10. K. Uludag, R. B. Buxton, “Measuring the effects of indomethacin
on changes in cerebral oxidative metabolism and cerebral blood flow during
sensorimotor activation”, Magnetic Resonance in Medicine 51(5),
1088-1089 (2004).
9. K. Uludag, J. Steinbrink, A. Villringer, H. Obrig, “Separability
and cross talk: optimizing dual wavelength combinations for near-infrared
spectroscopy of the adult head”, Neuroimage 22(2), 583-89 (2004).
8. M. L. Schroeter, M. B. Buecheler, K. Mueller, K. Uludag, H. Obrig,
G. Lohmann, M. Tittgemeyer, A. Villringer, Y. Von Cramon, “Towards
a standard analysis for functional near-infrared spectroscopy”,
Neuroimage 21(1), 283-90 (2004).
7. B.-M. Mackert, G. Wübbeler, S. Leistner, K. Uludag, H. Obrig,
A. Villringer, L. Trahms, G. Curio, “Neurovascular coupling analyzed
non-invasively in the human brain”, Neuroreport 15(1), 63-66 (2004).
6. K. Uludag, J. Steinbrink, M. Kohl-Bareis, R. Wenzel, A. Villringer,
H. Obrig, “Cytochrome-c-oxidase redox changes during visual stimulation
measured by near-infrared spectroscopy cannot be explained by a mere cross
talk artefact”, Neuroimage 22(1), 109-119 (2004).
5. S. J. Schreiber, U. Franke, F. Doepp, E. Staccioli, K. Uludag und J.
M. Valdueza, “Dopplersonographic measurement of global cerebral
circulation time using echo contrast enhanced ultrasound in normal individuals
and patients with arteriovenous malformations”, Ultrasound in Medicine
and Biology 28(4), 453-8 (2002).
4. H. Obrig, H. Israel, M. Kohl-Bareis, K. Uludag, R. Wenzel, B. Müller,
G. Arnold, A. Villringer, “Habituation of the Visually Evoked Potential
(VEP) and its Vascular Response: Implications for Neurovascular Coupling
in the Healthy Adult”, Neuroimage 17(1), 1-18 (2002).
3. M. Kohl, H. Obrig, J. Steinbrink, J. Malak, K. Uludag, A. Villringer,
“Noninvasive monitoring of cerebral blood flow by a dye bolus method:
Separation of brain from skin and skull signals”, Journal of Biomedical
Optics 7(3), 464-470, (2002).
2. K. Uludag, M. Kohl, J. Steinbrink, H. Obrig, A. Villringer, “Cross
talk in the Lambert-Beer calculation for near-infrared wavelengths estimated
by Monte Carlo simulations”, Journal of Biomedical Optics 7(1),
51–59 (2002).
1. M. Kohl, H. Obrig, J. Steinbrink, J. Malak, K. Uludag, A. Villringer,
“Noninvasive cerebral blood flow monitoring by a dye bolus method:
separation of extra- and intracerebral absorption changes by frequency
domain spectroscopy”, Proceedings of SPIE 4250, 296-300 (2001).
Awards
- October 2008 Teaching award at the Graduate School of Neural and Behavioral
Sciences
- November 2003: Price of the German Society of Neurology for the Poster
“Kortikale neuro-vaskuläre Kopplung – nicht-invasiv erfasst
mittels Magnetoencephalographie und Nahinfrarot-Spektroskopie”
- September 1997: Hereaus-Award for outstanding Diploma thesis
Professional and Scientific Societies
2003-present International Society of Magnetic Resonance in Medicine
2004-present Organization for Human Brain Mapping
2004-present Society for Neuroscience
2008-present European Society for Magnetic Resonance in Medicine and Biology
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